A01: The neural code of stimulus-triggered territorial aggression
A unique experimental model will be used to study the neurobiological basis of aggressive animal behavior and translate …
→Research Projects
Neuropsychobiology of Aggression
Research Areas
In its first funding period (2024-2028), TRR379 comprises 20 research projects, supported by four central service projects. Individual research projects are associated with three broader research areas within the consortium.
Area A: Negative valence system
A02: Context effects on threat processing in dependence of testosterone levels
The focus will be on the influences of a provocative context on social threat processing in AMD under different …
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A03: Modulation of aggression by acute threat
The neural and neurochemical patterns of acute threat as modulators of aggression in BPD will be investigated in this …
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A04: Implicit chemosensory threat signals as stimulators of amygdala hyperresponsiveness in AMD
We make use of threat-related chemosensory stimuli, namely body odor, acquired during aggressive behavior (boxing) and …
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A05: Peripersonal space violations and social threat: daily-life psychological and neural mechanisms of environmental risk for reactive aggression
Peripersonal space, the representation of the space immediately surrounding the body, will be studied as an underlying …
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A06: Decoding dynamic reciprocal neural mechanism underlying reactive aggression: Insights from fMRI and fNIRS hyperscanning
The project employs fMRI and functional near-infrared spectroscopy (fNIRS) hyperscanning techniques to explore how …
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A07: The intestinal microbiota as a regulator of aggressive and impulsive behavior
This translational project investigates sex-dependent behavioral effects of faecal microbiota transplantation to …
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A08: The metabolic lung-brain axis in aggressive behavior in patients with AMD
Beta-hydroxy-butyrate (BHB), a ketone body, is negatively associated with aggressive behavior. BHB is a metabolite and …
→Area B: Cognitive system
B01: Neurobehavioral effects of repetitive prefrontal transcranial direct current stimulation (tDCS) on pathological aggression
TDCS will be used as an interventional tool to decrease aggression. Using a simultaneous tDCS – fMRI approach, the …
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B02: Young offenders’ self-regulation deficit as a common mechanism for aggressive behavior and psychopathology - neural mechanisms and role of adverse childhood experiences
This project aims to identify cognitive and emotion control deficits in the context of negative valence and threat …
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B03: A process-based brain-computer interface to modulate aggressive behavior – a real-time fMRI neurofeedback study
Probe the self-regulation of CS networks in adults and adolescents diagnosed with mental disorders related to frequent …
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B04: Investigating psychological and neural correlates of intimate partner violence
Focus on the neural correlates of characterizing cognitive control deficits during conflict situations. The project will …
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B05: Predictors and (neuro-)biological correlates of (cyber-)bullying and victimization in real-life contexts
Focus on the investigation of a lack of cognitive control in bullies and victims that contributes to the risk of …
→Area C: Interaction of NVS & CS
C01: Gene-environment interactions and the role of impulsivity in responding to acute threats: early life stress and escalated aggression in recombinant inbred mouse strains
Sex-dependent effects and gene-environment interactions will be investigated by applying escalating aggression …
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C02: Aggressive decisions in social conflicts: Neuro-cognitive models for healthy individuals and psychiatric patients with high scores of aggression
Develop virtual scenarios to assess decision strategies in cartoon-like and naturalistic contexts. The core question is …
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C03: Distributed network control and interventions to frustrative non-reward and threat triggered aggressions
Investigate context-dependent aggression triggered by frustrative non-reward or acute social threats. Using newly …
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C04: The sex-specific role of genes, early adversity, peers, community violence, and puberty related endocrinological changes in adolescent pathological aggression
Address sex-specific NVS (reactive aggression) and CS (different dimensions of psychopathy, proactive aggression) …
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C05: The neuroanatomical underpinnings of clinical aggression and their relationship with the negative valence and cognitive control systems
Link questionnaire measures of aggression to specific neural substrates using structural MRI. The resulting patterns of …
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C06: Brain mechanisms differentiating aggressive vs. non-aggressive psychopathology as sequelae of early life maltreatment
Identify specific neuronal mechanisms related to the NVS and CS in female and male clinical samples with a history of …
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C07: Identifying mediators of threat-aggression and experimental manipulation by tDCS
Test the interaction of the CS and frustrative non-reward as part of the NVS. It will investigate the …
→Central Service Projects
Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span
The central recruitment platform for collecting and curating a longitudinal dataset for studying individual aggression …
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Q02: Data management for computational modelling
Data management and training platform. A decentralized data management infrastructure will help focus on developmental …
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Q03: Integrated Research Training Group (RTG)
Bundle all training and mentoring activities in a research training group (RTG) for the young researchers participating …
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Q04: Central coordination
Governance, and communication among participating researchers and the public.
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