A03: Modulation of aggression by acute threat
The neural and neurochemical patterns of acute threat as modulators of
aggression in BPD will be investigated in this project. The modulation of
aggressive responses under acute threat is induced by the threat-of-shock
paradigm. The main translational research question is if and how aggressive
responses are modulated by threat, and which neurofunctional and neurochemical
patterns underlie these responses during safe and threat conditions. MR
spectroscopy will be used in patients to assess glutamate and GABA levels. In a
further translational approach, the least and the most aggressive/impulsive
recombinant inbred mouse lines identified in
C01 in Frankfurt will be tested in Mannheim with animal MR spectroscopy at
9.4T to determine the relationship between glutamate, GABA, impulsivity, and
aggression in these mouse lines as well as in comparable brain regions
assessing neurofunctional and neurochemical patterns.
