↓Skip to main content
  1. Contributors/

Ph.D. Aet O'Leary

Principal investigator

Department of Psychiatry, University Hospital Frankfurt

0000-0001-6783-4729

Related content

Projects

C01: Gene-environment interactions and the role of impulsivity in responding to acute threats: early life stress and escalated aggression in recombinant inbred mouse strains

Aet O'Leary David Slattery Goethe University Frankfurt Interaction of negative valence system and cognitive system Biological Psychiatry
Sex-dependent effects and gene-environment interactions will be investigated by applying escalating aggression paradigms. Specifically, the project will investigate the effects of early life stress on aggression in response to threat and hyperactivity as well as social decision-making in 32 BXD mouse strains, the progenitor strains (C057Bl/6J and DBA/2J), and the F1 BXD cross. The project aims to identify the quantitative trait loci (QTL) and putative candidate genes contained within the QTL and associate them with specific behavioral responses of stressed and unstressed cohorts of mice. The publicly available database GeneNetwork (www.genenetwork.org) will be used to validate the findings which include measurements of mRNA and protein expression, and methylation patterns in mouse brains

Sites

Goethe University Frankfurt

Andreas G Chiocchetti Christine Ecker Christine Margarete Freitag Aet O'Leary Michael Plichta Andreas Reif David Slattery

Goethe University Frankfurt is known for its strong emphasis on research across diverse fields, including social sciences, humanities, and natural sciences. The university fosters a dynamic academic environment with a commitment to academic freedom and a focus on societal relevance and innovation.

Eingansgsbereich der Psychiatrie in Frankfurt
Welcome area at the Department of Psychiatry ©University of Frankfurt
Therapieraum der Psychiatrie in Frankfurt
Therapy at Department of Psychiatry ©University of Frankfurt